Eberechi Eze's hat-trick helped Arsenal claim a 4-1 north London derby win over Tottenham.
Scottish Premiership leaders Hearts suffered first defeat of the season in 1-0 loss at Aberdeen.
Ewan Ashman and George Horne scored two tries each as Scotland beat Tonga 56-0.
Kevin Danso starts as Tottenham select a back three at Arsenal, while Mohammed Kudus also features.
Piero Hincapie starts in place of Gabriel, while Mikel Merino continues up front for Arsenal.
Morgan Rogers scored twice as Aston Villa came from behind to win 2-1 at Leeds.
Tyrese Campbell's brace and a late Tom Cannon goal gave Sheff Utd a 3-0 win over Sheff Wed.