Bryan Mbeumo, Kobbie Mainoo, Diogo Dalot and Ayden Heaven start as four changes for Man United.
Enzo Fernandez and Liam Delap in for Andrey Santos and Joao Pedro as two Chelsea changes.
Georginio Rutter scored in stoppage time as Brighton twice came from behind in 2-2 draw at Tottenham
Alessia Russo scored the decisive goal as England Women won 1-0 in Iceland in WC qualifying.
Ellie Kildunne and Sarah Bern scored braces as England hammered Scotland 84-7 in Women's Six Nations
Tom Johnstone's four tries helped Wakefield beat Bradford 52-12 to go second in Betfred Super League
Fabian Hurzeler keeps faith with same starting XI from Brighton's 2-0 win over Burnley.