Harrison Reed and Antonee Robinson in for Ryan Sessegnon and Sander Berge as two Fulham changes.
Bukayo Saka makes first league start since March while Myles Lewis-Skelly also starts for Arsenal.
Ten-man Sunderland held to 1-1 draw at Wolves as European hopes dealt a huge blow.
Newcastle beat Brighton 3-1 to end run of five straight defeats and ease pressure on Eddie Howe.
Billy Loughnane, 20, aboard Bow Echo has won 2,000 Guineas for trainer George Boughey.
West Ham beaten 3-0 at Brentford to remain two points above Tottenham, having played a game more.
Hull City claim the final Championship play-off place after winning 2-1 at home to Norwich City.